Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation

Clin Appl Thromb Hemost. 2005 Oct;11(4):391-400. doi: 10.1177/107602960501100405.

Abstract

Plasma levels of granulocyte-derived elastase (GE-XDP), D-dimer, and soluble fibrin (SF) were examined in 177 patients with disseminated intravascular coagulation (DIC) of various etiologies. Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in patients with sepsis and solid cancer. The ratio of GE-XDP/ D-dimer was significantly high in patients with trauma, burn, and sepsis, suggesting that fibrinolysis due to GE-XDP may be dominant in DIC. Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in patients with overt DIC and correlated with DIC score. Plasma levels of GE-XDP, but not SF, correlated significantly with D-dimer. Plasma levels of D-dimer, but not SF, correlated significantly with plasmin plasmin inhibitor complex (PPIC). Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in nonsurvivors. Plasma levels of GE-XDP, but not SF, correlated significantly with sepsis-related organ failure assessment (SOFA) score. These results suggest that GE-XDP is a potentially useful marker for the diagnosis of overt-DIC and as a predictor of organ failure-related outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • Disseminated Intravascular Coagulation / blood*
  • Disseminated Intravascular Coagulation / enzymology*
  • Disseminated Intravascular Coagulation / pathology
  • Female
  • Fibrin / metabolism*
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Fibrinolysin / antagonists & inhibitors
  • Fibrinolysin / metabolism
  • Humans
  • Leukocyte Elastase / metabolism*
  • Male
  • Plasma / metabolism*
  • Protein Binding
  • Sepsis / blood
  • Sepsis / enzymology
  • Solubility

Substances

  • Biomarkers
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • Fibrin
  • Leukocyte Elastase
  • Fibrinolysin