Synthesis of a new N-9 ribityl analogue of cyclic inosine diphosphate ribose (cIDPR) as a mimic of cyclic ADP ribose (cADPR)

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):735-8. doi: 10.1081/ncn-200060041.

Abstract

A new analogue of cyclic inosine diphosphate ribose (cIDPR), in which the N-1 and N-9 ribosyl moieties were substituted by a carbocyclic moiety and a hydroxyl-alkyl chain, has been synthesized and characterized.

MeSH terms

  • Chemistry, Pharmaceutical
  • Chromatography, High Pressure Liquid
  • Cyclic ADP-Ribose / analogs & derivatives*
  • Cyclic ADP-Ribose / chemical synthesis
  • Cyclic ADP-Ribose / chemistry
  • Drug Design
  • Glycoside Hydrolases / chemistry
  • Hydrolysis
  • Inosine / chemistry*
  • Inositol 1,4,5-Trisphosphate / chemistry
  • Models, Chemical
  • Molecular Biology / methods
  • Phosphates / chemistry*
  • Ribose / chemistry*

Substances

  • Phosphates
  • Cyclic ADP-Ribose
  • Inosine
  • Ribose
  • Inositol 1,4,5-Trisphosphate
  • Glycoside Hydrolases