Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0

Christopher J Welch; Jimmy O DaSilva; Joseph Nti-Gyabaah; Firoz Antia; Kent Goklen; Russell Boyd

doi:10.1016/j.chroma.2005.10.009

Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0

J Chromatogr A. 2006 Jan 6;1101(1-2):204-13. doi: 10.1016/j.chroma.2005.10.009. Epub 2005 Oct 27.

Authors

Christopher J Welch¹, Jimmy O DaSilva, Joseph Nti-Gyabaah, Firoz Antia, Kent Goklen, Russell Boyd

Affiliation

¹ Merck Research Laboratories, Merck & Co. Inc., Rahway, NJ 07065, USA.

PMID: 16257000
DOI: 10.1016/j.chroma.2005.10.009

Abstract

Preparation and evaluation of a number of stationary phases for improved chromatographic purification of pneumocandin B0, a key intermediate in the synthesis of the antifungal agent, Cancidas, has led to the identification of several materials with potential for improved performance.

Publication types

Evaluation Study

MeSH terms

Chromatography, High Pressure Liquid / instrumentation
Chromatography, High Pressure Liquid / methods*
Echinocandins
Peptides, Cyclic / isolation & purification*
Silicon Dioxide

Substances

Echinocandins
Peptides, Cyclic
pneumocandin B(0)
Silicon Dioxide