Abstract
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.
MeSH terms
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Analgesics, Opioid / chemical synthesis*
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Analgesics, Opioid / therapeutic use
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Animals
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Binding Sites
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Codeine / chemistry
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Codeine / therapeutic use
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Models, Chemical
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Morphine / chemistry
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Morphine / therapeutic use
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Pain / drug therapy
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Rats
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Time Factors
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Tramadol / analogs & derivatives
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Tramadol / chemical synthesis*
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Tramadol / therapeutic use
Substances
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Analgesics, Opioid
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Tramadol
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Morphine
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Codeine