Rh-catalyzed enantioselective diboration of simple alkenes: reaction development and substrate scope

J Org Chem. 2005 Nov 11;70(23):9538-44. doi: 10.1021/jo051651m.

Abstract

[Reaction: see text]. The rhodium-catalyzed reaction between bis(catecholato)diboron and simple alkenes results in the syn addition of the diboron across the alkene. The resulting 1,2-bis(boronate) is subsequently oxidized to provide the 1,2-diol. In the presence of enantiomerically enriched Quinap ligand, high enantioselection in the diboration can be achieved. The reaction is highly selective for trans- and trisubstituted alkenes and can be selective for some monosubstituted alkenes as well. The development of this reaction is described as is the substrate scope and experiments that are informative about the reaction mechanism and competing pathways.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkenes / chemistry*
  • Boron Compounds / chemistry*
  • Catalysis
  • Ligands
  • Molecular Structure
  • Oxidation-Reduction
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Boron Compounds
  • Ligands
  • Rhodium