Abstract
Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.
MeSH terms
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Amides
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Antimetabolites / chemical synthesis*
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Antimetabolites / chemistry
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Antimetabolites / therapeutic use
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / therapeutic use
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DNA Viruses*
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / therapeutic use
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Ribonucleosides / chemical synthesis*
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Ribonucleosides / chemistry
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Ribonucleosides / therapeutic use
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Ribose
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Structure-Activity Relationship
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Virus Diseases / drug therapy*
Substances
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Amides
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Antimetabolites
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Antiviral Agents
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Pyrazoles
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Ribonucleosides
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pyrazole
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pyrazofurin
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Ribose