Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone

Nikhil H Gokhale; K Shirisha; Subhash B Padhye; Simon L Croft; Howard D Kendrick; Vickie Mckee

doi:10.1016/j.bmcl.2005.09.061

Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone

Bioorg Med Chem Lett. 2006 Jan 15;16(2):430-2. doi: 10.1016/j.bmcl.2005.09.061. Epub 2005 Nov 3.

Authors

Nikhil H Gokhale¹, K Shirisha, Subhash B Padhye, Simon L Croft, Howard D Kendrick, Vickie Mckee

Affiliation

¹ Department of Chemistry, University of Pune, Ganeshkhind Road, Pune-411007, India.

PMID: 16275074
DOI: 10.1016/j.bmcl.2005.09.061

Abstract

The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target.

MeSH terms

Animals
Antimalarials* / chemical synthesis
Antimalarials* / chemistry
Antimalarials* / pharmacology
Copper / chemistry*
Crystallization
Crystallography, X-Ray
Models, Molecular
Molecular Structure
Naphthoquinones / chemistry*
Organometallic Compounds* / chemical synthesis
Organometallic Compounds* / chemistry
Organometallic Compounds* / pharmacology
Parasitic Sensitivity Tests
Plasmodium falciparum / drug effects*

Substances

Antimalarials
Naphthoquinones
Organometallic Compounds
Copper