[Catalytic autoantibodies in autoimmune myocarditis: clinical and pathogenetic implications]

Ter Arkh. 2005;77(9):65-70.
[Article in Russian]

Abstract

Aim: To evaluate pathogenetic and clinical significance of autoantibodies (AAB) with catalytic activity in the serum of patients with autoimmune myocarditis (AM).

Material and methods: The study was made on the sera from 99 patients with AM of different course: malignant, benign, myocardiosclerosis (MCS). In addition to standard immunological parameters, the study was made of serum levels of anticardiomyosine-antiCM (protabzymes) and anti-DNA (DNA-abzymes) of AAB. After obtaining anti-CM and anti-DNA IgG-AT, we determined non-specific and specific proteolytic activity of anti-CM.

Results: Maximal specific activity of protabzymes was seen in 73% patients with malignant AM, it correlated with blood levels of anti-CM AAB, DNA-abzymes activity was very high in 45% patients. In MCS proteolytic activity of autoAT was absent in 61% patients. In benign AM occurrence of protabzymes was confirmed in 35% cases. Elevated DNA-hydrolyzing activity of DNA-abzymes occurred in 13% cases. The activity had no significant correlation with serum titers of AB. In MCS proteolytic activity of AAB was absent in 61% cases, but high activity of anti-CM AAB was in 28%. The activity of DNA-abzymes in 44% ranged considerably which, in seropositive cases, detected significant correlation with serum titers of DNA-binding autoAT.

Conclusion: Evaluation of catalytic activity of AAB may be considered as a criterial test assessing the stage, clinical variants and severity of AM. It also permits formulation of the disease prognosis and its possible outcomes.

Publication types

  • English Abstract

MeSH terms

  • Antibodies, Catalytic / blood*
  • Antibodies, Catalytic / metabolism
  • Autoantibodies / blood*
  • Autoantibodies / genetics
  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / immunology
  • Cardiac Myosins / immunology
  • Catalysis
  • DNA / immunology
  • Humans
  • Immunoglobulin G / genetics
  • Myocarditis / diagnosis*
  • Myocarditis / immunology
  • Prognosis

Substances

  • Antibodies, Catalytic
  • Autoantibodies
  • Immunoglobulin G
  • DNA
  • Cardiac Myosins