Critical role of ITIM-bearing FcgammaR on DCs in the capture and presentation of native antigen to B cells

Bertrand Dubois; Christophe Caux

doi:10.1016/j.immuni.2005.10.005

Critical role of ITIM-bearing FcgammaR on DCs in the capture and presentation of native antigen to B cells

Immunity. 2005 Nov;23(5):463-4. doi: 10.1016/j.immuni.2005.10.005.

Authors

Bertrand Dubois¹, Christophe Caux

Affiliation

¹ INSERM U404 "Immunité et Vaccination", IFR-128 Biosciences Lyon Gerland, 21 avenue Tony Garnier, 69365 Lyon Cedex 07, France.

PMID: 16286014
DOI: 10.1016/j.immuni.2005.10.005

Abstract

The contribution of dendritic cells (DCs) to antibody responses through antigen-unspecific B cell costimulation is well documented. now demonstrate that the ITIM-bearing FcgammaRIIB allows DCs to recycle internalized native antigen (Ag) for presentation to B cells, a process that might be critical for the initiation of humoral responses.

MeSH terms

Animals
Antigen Presentation*
Antigens / immunology*
Antigens / metabolism
B-Lymphocytes / immunology*
B-Lymphocytes / metabolism
Dendritic Cells / immunology*
Dendritic Cells / metabolism
Humans
Receptors, IgG / immunology*

Substances

Antigens
Receptors, IgG