Failure of HIV-2 viral load assay in a severely immunodeficient patient: clinical and therapeutic management issues

Laurent Fonquernie; Serge P Eholié; Florence Damond; Karine Lacombe; Pierre-Marie Girard

doi:10.1016/j.trstmh.2005.08.007

Failure of HIV-2 viral load assay in a severely immunodeficient patient: clinical and therapeutic management issues

Trans R Soc Trop Med Hyg. 2006 Mar;100(3):282-4. doi: 10.1016/j.trstmh.2005.08.007. Epub 2005 Nov 15.

Authors

Laurent Fonquernie¹, Serge P Eholié, Florence Damond, Karine Lacombe, Pierre-Marie Girard

Affiliation

¹ Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184 rue du faubourg Saint-Antoine, 75012 Paris, France. laurent.fonquernie@sat.ap-hop-paris.fr

PMID: 16293278
DOI: 10.1016/j.trstmh.2005.08.007

Abstract

We report the case of an HIV-2-infected patient with severe immunosupression despite undetectable plasma HIV-2 RNA. This immunovirological discordance was due to failure of the viral load assay and infection by an unknown HIV-2 subtype. Treatment was probably suboptimal, leading to the selection of several resistance mutations and treatment failure.

Publication types

Case Reports

MeSH terms

Adult
Anti-HIV Agents / therapeutic use
HIV Infections / drug therapy
HIV Infections / virology*
HIV-2 / genetics*
HIV-2 / isolation & purification
Humans
Male
RNA, Viral / blood*
Treatment Failure
Viral Load* / methods
Viral Load* / standards

Substances

Anti-HIV Agents
RNA, Viral