Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis

Kristin J Carpenter; Karen F Buckland; Zhou Xing; Cory M Hogaboam

doi:10.1128/IAI.73.12.8402-8406.2005

Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis

Infect Immun. 2005 Dec;73(12):8402-6. doi: 10.1128/IAI.73.12.8402-8406.2005.

Authors

Kristin J Carpenter¹, Karen F Buckland, Zhou Xing, Cory M Hogaboam

Affiliation

¹ Department of Pathology, University of Michigan Medical School, Rm. 5216B, Med. Sci. I, 1301 Catherine Road, Ann Arbor, MI 48109-0602, USA.

Abstract

Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Adaptor Proteins, Signal Transducing / metabolism
Adenoviridae / genetics*
Animals
Aspergillosis / genetics
Aspergillosis / immunology*
Aspergillus fumigatus* / immunology
Immunity, Innate / genetics
Lung / microbiology
Lung / pathology
Lung Diseases, Fungal / genetics
Lung Diseases, Fungal / immunology*
Mice
Mice, Mutant Strains
Neutropenia / genetics
Transcriptional Activation

Substances

Adaptor Proteins, Signal Transducing
Tyrobp protein, mouse