In patients refusing implant surgery for psychological reasons, when minimal tooth reduction is desired, a fiber-reinforced composite inlay fixed partial denture (IFPD) can be used to replace missing teeth. In comparison to other restorative systems this conservative approach carries a lower risk of pulp exposure and/or periodontal inflammation, maintaining the health of supporting tissues. The purpose of this case report is to describe the clinical procedure for fabricating an IFPD with a pre-impregnated glass fiber system and a hybrid composite. Fiber-reinforced composite, in combination with adhesive techniques, appears promising for an IFPD. Further clinical investigation will be required to provide additional information on this technique.