Nfl gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways

Leukemia. 2006 Jan;20(1):151-4. doi: 10.1038/sj.leu.2404033.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Cytarabine / pharmacology
  • Cytarabine / therapeutic use*
  • Drug Resistance, Neoplasm
  • Humans
  • Leukemia, Myeloid / drug therapy
  • Leukemia, Myeloid / metabolism*
  • Mice
  • Mitogen-Activated Protein Kinases / metabolism*
  • Neurofibromin 1 / deficiency
  • Neurofibromin 1 / genetics*
  • Neurofibromin 1 / metabolism
  • Protein Kinases / metabolism*
  • Signal Transduction / drug effects
  • TOR Serine-Threonine Kinases

Substances

  • Neurofibromin 1
  • Cytarabine
  • Protein Kinases
  • MTOR protein, human
  • mTOR protein, mouse
  • TOR Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinases