Dephosphorylation shows SR proteins the way out

Mol Cell. 2005 Nov 23;20(4):499-501. doi: 10.1016/j.molcel.2005.11.005.

Abstract

To address the role of the RS domain in shuttling and how it is differentially required for constitutive and alternative splicing, Lin et al. (2005 [in the November 11 issue of Molecular Cell]) employ an elegant somatic complementation system to reveal a novel phosphorylation-dependent mechanism regulating distinct recycling pathways for SR proteins during mRNP maturation.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Phosphoproteins / chemistry
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism*
  • Phosphorylation
  • Protein Transport / genetics
  • RNA-Binding Proteins
  • Ribonucleoproteins / metabolism
  • Serine-Arginine Splicing Factors

Substances

  • Nuclear Proteins
  • Phosphoproteins
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • messenger ribonucleoprotein
  • Serine-Arginine Splicing Factors