Abstract
We transplanted kidneys from alpha1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified*
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Antibodies / blood
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Galactosyltransferases / genetics
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Galactosyltransferases / immunology
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Graft Rejection / immunology*
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Immune Tolerance / immunology*
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Immunosuppression Therapy / methods
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Kidney Transplantation / immunology*
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Papio
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Sus scrofa / genetics
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T-Lymphocytes / immunology
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Transplantation, Heterologous / immunology
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Transplantation, Heterologous / methods*
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Transplantation, Heterologous / mortality*
Substances
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Antibodies
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Galactosyltransferases