Latent acute promyelocytic leukemia t(15;17)(q22;q12-21) and sarcoidosis: long-term cohabitation

V Leymarie; A C Galoisy; A Falkenrodt; S Natarajan-Ame; P Dufour; M Lessard

doi:10.1016/j.ejim.2005.04.009

Latent acute promyelocytic leukemia t(15;17)(q22;q12-21) and sarcoidosis: long-term cohabitation

Eur J Intern Med. 2005 Dec;16(8):598-600. doi: 10.1016/j.ejim.2005.04.009.

Authors

V Leymarie¹, A C Galoisy, A Falkenrodt, S Natarajan-Ame, P Dufour, M Lessard

Affiliation

¹ Laboratory of Hematology, Hautepierre University Hospital, avenue Moliere, F-67098 Strasbourg Cedex, France. vincent.leymarie@chru-strasbourg.fr

PMID: 16314244
DOI: 10.1016/j.ejim.2005.04.009

Abstract

The association of sarcoidosis with hematological malignancies is a well-known phenomenon. To our knowledge, we report the first case involving sarcoidosis and acute promyelocytic leukemia (APL) t(15;17)(q22;q12-21). The major interest lies in the chronology of the two diseases: the APL demonstrated an unusual smoldering evolution, suggesting that pre-existing sarcoidosis may have a non-fortuitous immunological impact on leukemic clone proliferation.