Chronic rhinosinusitis and superantigens

Otolaryngol Clin North Am. 2005 Dec;38(6):1215-36, ix. doi: 10.1016/j.otc.2005.08.006.

Abstract

This article discusses the potential role of bacterial superantigens (SAgs) in chronic rhinosinusitis with nasal polyposis (CRS/NP). First, it briefly describes SAgs, focusing on how they interact with the immune system by binding to T-cell receptors (TCR) and major histocompatibility complex (MHC) class II molecules. Second, it discusses the role of SAgs in other chronic inflammatory diseases.Finally, it presents evidence for the role of SAgs in the pathogenesis and maintenance of CRS/NP focusing on current research and future considerations.

Publication types

  • Review

MeSH terms

  • Chronic Disease
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Nasal Polyps / immunology
  • Receptors, Antigen, T-Cell / immunology
  • Rhinitis / immunology*
  • Sinusitis / immunology*
  • Superantigens / immunology*

Substances

  • Histocompatibility Antigens Class II
  • Receptors, Antigen, T-Cell
  • Superantigens