Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?

Sci STKE. 2005 Dec 6;2005(313):pe53. doi: 10.1126/stke.3132005pe53.

Abstract

The endoplasmic reticulum (ER) is not simply a uniform continuous organelle, but is spatially and functionally heterogeneous with nonuniform distribution of endoplasmic Ca(2+)-handling proteins, such as Ca(2+)-binding proteins, Ca(2+) pumps, and Ca(2+)-release channels. Such nonuniform distribution of Ca(2+)-handling proteins is thought to create a spatially divided calcium store and to contribute to the generation of complex intracellular Ca(2+) dynamics. In addition to the particular distribution of these Ca(2+)-handling proteins within ER, extracellular stimuli may also stimulate the formation of dynamic new ER compartments containing Ca(2+)-handling proteins. These compartments containing Ca(2+)-handling proteins have potential roles in Ca(2+) signaling; specifically, they may function as "induced coupling domains" between the ER and plasma membrane, thereby allowing Ca(2+) entry into the ER.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Channels / physiology
  • Calcium Signaling / physiology*
  • Cell Compartmentation*
  • Drosophila Proteins / physiology
  • Drosophila melanogaster / physiology
  • Endoplasmic Reticulum / physiology*
  • Endoplasmic Reticulum / ultrastructure
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins / physiology
  • Multiprotein Complexes
  • Neoplasm Proteins / physiology
  • RNA Interference
  • Receptors, Cytoplasmic and Nuclear / physiology
  • Stromal Interaction Molecule 1
  • Type C Phospholipases / physiology

Substances

  • Calcium Channels
  • Drosophila Proteins
  • ITPR1 protein, human
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins
  • Multiprotein Complexes
  • Neoplasm Proteins
  • Receptors, Cytoplasmic and Nuclear
  • STIM1 protein, human
  • Stim protein, Drosophila
  • Stromal Interaction Molecule 1
  • Type C Phospholipases