Assessment of the post-resectional functioning liver parenchyma is one of the most important issues in operation planning of liver resections. However, preoperative assessment of the future liver remnant's vascularization is in particular difficult in repeated hepatectomy because of the often altered intrahepatic vascular system after prior vascular dissection. Therefore, in these resections preoperative calculation of the remaining liver parenchyma with unimpaired vascular function is uncertain and imprecise. Based on the case of a 62-year-old woman with a recurrent colorectal liver metastasis in segments VII and VIII after prior left-lateral liver resection (segments II/III) we describe the potential use of computer-assisted operation planning for assessment of functional resectability in repeated hepatectomy.