Screening for undiagnosed parkinsonism in people aged 65 years and over in the community

Parkinsonism Relat Disord. 2006 Mar;12(2):79-85. doi: 10.1016/j.parkreldis.2005.08.005. Epub 2005 Dec 9.

Abstract

We screened a random sample of 2449 people aged 65 years and over for undiagnosed parkinsonism, using a postal screening questionnaire followed by clinical neurological assessment. Amongst the 1556 (63.5%) patients who responded, four patients with previously undiagnosed parkinsonism were identified, suggesting a prevalence of 257 per 100,000 (95% CI 70, 658) in this age-group. Although only small, the numbers were sufficient to significantly increase the incidence of parkinsonism in an incidence study. Two simple screening questions achieved a high sensitivity for newly diagnosed parkinsonism of 95%, but a low specificity of 28%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged / physiology*
  • Aged, 80 and over
  • Data Interpretation, Statistical
  • Female
  • Humans
  • Male
  • Mass Screening
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / psychology
  • Quality of Life
  • ROC Curve
  • Sample Size
  • Surveys and Questionnaires
  • United Kingdom / epidemiology