Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling

Bioorg Med Chem. 2006 May 1;14(9):2904-9. doi: 10.1016/j.bmc.2005.12.005. Epub 2006 Jan 11.

Abstract

A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTc-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.

MeSH terms

  • Animals
  • Chelating Agents / chemical synthesis*
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacokinetics*
  • Ligands
  • Male
  • Molecular Structure
  • Rats
  • Rats, Wistar
  • Rhenium / chemistry
  • Technetium / chemistry*

Substances

  • Chelating Agents
  • Ligands
  • Rhenium
  • Technetium