Abstract
Abnormal levels of interleukin (IL)-6 were described in patients with ALS, related to an inflammatory process. The authors compared IL-6 and tumor necrosis factor alpha (TNF-alpha) levels in CSF and sera from 10 hypoxemics and 10 normoxemics patients with ALS to those of 10 hypoxemics and 10 normoxemics neurologic controls. The same pattern exists in patients with ALS and controls: the highest levels are found in hypoxic conditions and undetectable levels are found in normoxemic conditions. Elevated IL-6 levels in ALS could correspond to a normal response to hypoxemia.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Amyotrophic Lateral Sclerosis / complications
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Amyotrophic Lateral Sclerosis / diagnosis*
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Amyotrophic Lateral Sclerosis / immunology*
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Biomarkers / blood
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Biomarkers / cerebrospinal fluid
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Female
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Humans
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Hypoxia / immunology*
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Hypoxia / physiopathology
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Interleukin-6 / blood
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Interleukin-6 / cerebrospinal fluid
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Interleukin-6 / immunology*
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Male
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Microglia / immunology
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Microglia / pathology
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Middle Aged
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Myelitis / immunology
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Myelitis / pathology
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Myelitis / physiopathology
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Oxidative Stress / immunology
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Predictive Value of Tests
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Respiratory Insufficiency / immunology
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Respiratory Insufficiency / physiopathology
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Respiratory Muscles / physiopathology
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Tumor Necrosis Factor-alpha / cerebrospinal fluid
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Tumor Necrosis Factor-alpha / immunology*
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Up-Regulation / immunology
Substances
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Biomarkers
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Interleukin-6
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Tumor Necrosis Factor-alpha