Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus

R Ni; K Ihara; K Miyako; M Takemoto; M Ishimura; H Kohno; N Matsuura; A Yoshimura; T Hara

doi:10.1111/j.1744-313X.2006.00563.x

Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus

Int J Immunogenet. 2006 Feb;33(1):7-10. doi: 10.1111/j.1744-313X.2006.00563.x.

Authors

R Ni¹, K Ihara, K Miyako, M Takemoto, M Ishimura, H Kohno, N Matsuura, A Yoshimura, T Hara

Affiliation

¹ Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan.

PMID: 16426235
DOI: 10.1111/j.1744-313X.2006.00563.x

Abstract

Suppressors of cytokine signalling (SOCS) proteins play important roles in the negative regulation of cytokine signal. We first searched for polymorphisms in SOCS-1, SOCS-3 and SOCS-5 genes, and examined the association of the polymorphisms with type 1 diabetes (T1D). As a result, we did not find any significant associations between SOCS genes and T1D.

MeSH terms

Case-Control Studies
Diabetes Mellitus, Type 1 / etiology
Diabetes Mellitus, Type 1 / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Molecular Sequence Data
Open Reading Frames
Polymorphism, Single Nucleotide
Suppressor of Cytokine Signaling Proteins / genetics*

Substances

Suppressor of Cytokine Signaling Proteins