Epstein-Barr virus-associated bronchial leiomyoma in a boy with cellular immunodeficiency

Pediatr Pulmonol. 2006 Apr;41(4):371-3. doi: 10.1002/ppul.20375.

Abstract

Bronchial leiomyoma is a rare disease in children. Recently, the association of leiomyoma and HIV infection was reported. We describe a boy with a cellular immunodeficiency, who had endobronchial leiomyoma. The tumor cells were positive for Epstein-Barr virus-encoded RNA-1 (EBER-1) and Epstein-Barr virus-determined nuclear antigen-2, suggesting a role of Epstein-Barr virus in the pathogenesis of leiomyoma.

Publication types

  • Case Reports

MeSH terms

  • Bronchial Neoplasms / complications
  • Bronchial Neoplasms / surgery
  • Bronchial Neoplasms / virology*
  • Child
  • Complement C2 / deficiency
  • Complement C9 / deficiency
  • Epstein-Barr Virus Nuclear Antigens / analysis*
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Leiomyoma / complications
  • Leiomyoma / surgery
  • Leiomyoma / virology*
  • Male
  • RNA, Viral / analysis*
  • Tumor Virus Infections / genetics

Substances

  • Complement C2
  • Complement C9
  • Epstein-Barr Virus Nuclear Antigens
  • Epstein-Barr virus encoded RNA 1
  • RNA, Viral