A concise total synthesis of naamidine A

Nicholas S Aberle; Guillaume Lessene; Keith G Watson

doi:10.1021/ol052568o

A concise total synthesis of naamidine A

Org Lett. 2006 Feb 2;8(3):419-21. doi: 10.1021/ol052568o.

Authors

Nicholas S Aberle¹, Guillaume Lessene, Keith G Watson

Affiliation

¹ Medicinal Chemistry Group, The Walter and Eliza Hall Institute of Medical Research, Biotechnology Centre, 4 Research Avenue, Bundoora 3086, Victoria, Australia.

PMID: 16435849
DOI: 10.1021/ol052568o

Abstract

[reaction: see text]. A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensation of the appropriate alpha-aminoketone with cyanamide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Products / chemical synthesis*
Imidazoles / chemical synthesis*
Molecular Structure
Porifera / chemistry

Substances

Biological Products
Imidazoles
naamidine A