APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count

J Virol. 2006 Feb;80(4):2069-72. doi: 10.1128/JVI.80.4.2069-2072.2006.

Abstract

APOBEC3F and APOBEC3G (hA3F and hA3G) are part of an innate mechanism of antiretroviral defense. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif targets both proteins for proteasomal degradation. Using mRNA from peripheral blood mononuclear cells of 92 HIV-infected subjects not taking antiretroviral therapy and 19 HIV-uninfected controls, we found that hA3F (P < 0.001) and hA3G (P = 0.016) mRNA levels were lower in HIV-infected subjects and were positively correlated with one another (P = 0.003). However, we found no correlation in the abundance of either hA3F or hA3G mRNA with either viral load or CD4 counts in HIV-infected subjects.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • APOBEC-3G Deaminase
  • CD4 Lymphocyte Count
  • Cells, Cultured
  • Cytidine Deaminase
  • Cytosine Deaminase / genetics*
  • HIV Infections / immunology
  • HIV Infections / virology*
  • HIV-1 / isolation & purification
  • HIV-1 / physiology*
  • Humans
  • Leukocytes, Mononuclear / chemistry
  • Nucleoside Deaminases / genetics*
  • RNA, Messenger / analysis*
  • Repressor Proteins / genetics*
  • Viral Load*
  • Viremia

Substances

  • RNA, Messenger
  • Repressor Proteins
  • Nucleoside Deaminases
  • APOBEC3F protein, human
  • Cytosine Deaminase
  • APOBEC-3G Deaminase
  • APOBEC3G protein, human
  • Cytidine Deaminase