Calcium-activated potassium channels and the regulation of vascular tone

Jonathan Ledoux; Matthias E Werner; Joseph E Brayden; Mark T Nelson

doi:10.1152/physiol.00040.2005

Calcium-activated potassium channels and the regulation of vascular tone

Physiology (Bethesda). 2006 Feb:21:69-78. doi: 10.1152/physiol.00040.2005.

Authors

Jonathan Ledoux¹, Matthias E Werner, Joseph E Brayden, Mark T Nelson

Affiliation

¹ Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA.

PMID: 16443824
DOI: 10.1152/physiol.00040.2005

Abstract

Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.

Publication types

Review

MeSH terms

Animals
Blood Pressure
Calcium / physiology
Cardiovascular Diseases / physiopathology
Cardiovascular Diseases / prevention & control
Cardiovascular Diseases / therapy
Endothelium, Vascular / physiology*
Humans
Muscle, Smooth, Vascular / physiology*
Potassium Channels, Calcium-Activated / classification
Potassium Channels, Calcium-Activated / physiology*
Potassium Channels, Calcium-Activated / ultrastructure
Signal Transduction

Substances

Potassium Channels, Calcium-Activated
Calcium