Abstract
Submandibular glands of rats injected with NaF solution (10 mg F-/kg body weight) were analysed for glycogen content and phosphorylase activity after various time intervals. In contrast to what has been reported for the liver, sodium fluoride caused increased glycogen content. Phosphorylase (a and total) activity was not affected, suggesting a different mechanism of action of F- in the submandibular gland. In vivo experiments demonstrated stimulation of glycogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drug Administration Schedule
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Glycogen / analysis
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Glycogen / metabolism*
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Male
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Phosphorylase a / analysis
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Phosphorylase a / metabolism
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Rats
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Rats, Inbred Strains
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Sodium Fluoride / administration & dosage
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Sodium Fluoride / pharmacology*
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Starvation
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Submandibular Gland / chemistry
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Submandibular Gland / drug effects
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Submandibular Gland / metabolism*
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Time Factors
Substances
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Sodium Fluoride
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Glycogen
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Phosphorylase a