Abstract
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
MeSH terms
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Aminopyridines / chemistry*
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Aminopyridines / pharmacology
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Binding Sites
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Crystallography, X-Ray
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Drug Design
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Factor VIIa / antagonists & inhibitors*
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Fibrinolytic Agents / chemical synthesis*
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Fibrinolytic Agents / pharmacology
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology
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Humans
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Structure-Activity Relationship
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Thromboplastin / antagonists & inhibitors*
Substances
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Aminopyridines
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Fibrinolytic Agents
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Heterocyclic Compounds
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Thromboplastin
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Factor VIIa