Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations

Ralf Dürrwald; Jolanta Kolodziejek; Aemero Muluneh; Sibylle Herzog; Norbert Nowotny

doi:10.1016/j.micinf.2005.08.013

Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations

Microbes Infect. 2006 Mar;8(3):917-29. doi: 10.1016/j.micinf.2005.08.013. Epub 2006 Jan 6.

Authors

Ralf Dürrwald¹, Jolanta Kolodziejek, Aemero Muluneh, Sibylle Herzog, Norbert Nowotny

Affiliation

¹ Impfstoffwerk Dessau-Tornau GmbH (IDT), Streetzer Weg 15a, D-06862 Rodleben, Germany.

PMID: 16469519
DOI: 10.1016/j.micinf.2005.08.013

Abstract

Classical Borna disease (cBD), a non-purulent encephalitis of solipeds and sheep, is endemic in certain areas of central Europe. The etiologic agent is Borna disease virus (BDV), thus far the only member of the family Bornaviridae. Based on epidemiological patterns of cBD and recent phylogenetic findings this review hypothesizes the possible existence of yet unknown BDV reservoir host populations, and analyzes critically BDVs from outside endemic regions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Borna Disease / epidemiology*
Borna Disease / virology*
Borna disease virus / genetics*
Disease Reservoirs
Genetic Variation