Abstract
Neurological disorders are a common cause of morbidity and mortality in the acquired immunodeficiency syndrome (AIDS). In this report we describe the neuropathological changes associated with both human immunodeficiency virus (HIV) infection and with the major opportunistic virus infections, cytomegalovirus (CMV), JC papovavirus (JCV) and herpes simplex virus (HSV) seen in AIDS. In addition "in situ" hybridization studies have been employed for the detection of virus genomic material in each case and the usefulness of this method in supporting the pathological diagnosis is demonstrated. Mechanisms whereby HIV infection results in leukoencephalopathy and the possible contributing roles of the three opportunistic virus infections are discussed.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Acquired Immunodeficiency Syndrome / complications*
-
Acquired Immunodeficiency Syndrome / pathology
-
Adult
-
Aged
-
Central Nervous System / microbiology
-
Central Nervous System / pathology
-
Central Nervous System Diseases / complications*
-
Central Nervous System Diseases / microbiology
-
Central Nervous System Diseases / pathology
-
Cytomegalovirus / isolation & purification
-
Cytomegalovirus Infections / complications*
-
Cytomegalovirus Infections / pathology
-
DNA, Viral / genetics
-
Herpes Simplex / complications*
-
Herpes Simplex / pathology
-
Humans
-
Male
-
Nucleic Acid Hybridization
-
Opportunistic Infections / complications*
-
Opportunistic Infections / microbiology
-
Opportunistic Infections / pathology
-
Papillomaviridae / isolation & purification
-
Polyomaviridae
-
Simplexvirus / isolation & purification
-
Tumor Virus Infections / complications*
-
Tumor Virus Infections / pathology