Recurrent Salmonella bacteremia in interleukin-12 receptor beta1 deficiency

J Trop Pediatr. 2006 Aug;52(4):296-8. doi: 10.1093/tropej/fml001. Epub 2006 Mar 10.

Abstract

Interleukin-12 receptor beta1 IL12RB1 deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp.

Publication types

  • Case Reports

MeSH terms

  • Bacteremia / metabolism
  • Bacteremia / microbiology*
  • Child, Preschool
  • Female
  • Humans
  • Receptors, Interleukin / deficiency*
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin-12
  • Salmonella / isolation & purification*
  • Salmonella Infections / genetics
  • Salmonella Infections / metabolism*

Substances

  • IL12RB1 protein, human
  • Receptors, Interleukin
  • Receptors, Interleukin-12

Associated data

  • OMIM/209950