Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis

J Nat Prod. 2006 Mar;69(3):397-9. doi: 10.1021/np058070c.

Abstract

As part of a study on potential antitumor agents from rainforest plants, two new pterocarpans, rautandiol A (1) and rautandiol B (2), together with eight known compounds, were isolated from Neorautanenia mitis. Among the compounds isolated, rotenone (3) and 12-hydroxyrotenone (4) showed significant cytotoxic activity with IC(50) values of 0.008-0.010 and 0.04-0.06 microg/mL against MCF-7 and A-549 cells, respectively.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Drug Screening Assays, Antitumor
  • Fabaceae / chemistry*
  • Female
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Pterocarpans / chemistry
  • Pterocarpans / isolation & purification*
  • Pterocarpans / pharmacology*
  • Tanzania
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Pterocarpans
  • rautandiol A
  • rautandiol B