Familial aggregation of sinonasal polyps correlates with severity of disease

Noam A Cohen; Jeffrey S Widelitz; Alexander G Chiu; James N Palmer; David W Kennedy

doi:10.1016/j.otohns.2005.11.042

Familial aggregation of sinonasal polyps correlates with severity of disease

Otolaryngol Head Neck Surg. 2006 Apr;134(4):601-4. doi: 10.1016/j.otohns.2005.11.042.

Authors

Noam A Cohen¹, Jeffrey S Widelitz, Alexander G Chiu, James N Palmer, David W Kennedy

Affiliation

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA, USA. cohenn@uphs.upenn.edu

PMID: 16564380
DOI: 10.1016/j.otohns.2005.11.042

Abstract

Objective: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP.

Study design and setting: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance).

Results: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs.

Conclusions: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity.

Ebm rating: B-2b.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Bias
Family*
Female
Genetic Predisposition to Disease
Humans
Incidence
Male
Nasal Polyps / epidemiology*
Nasal Polyps / genetics
Paranasal Sinus Diseases / epidemiology*
Paranasal Sinus Diseases / genetics
Polyps / epidemiology
Polyps / genetics
Severity of Illness Index
Sex Distribution
Surveys and Questionnaires