Abstract
We describe a case of an HIV-infected intravenous drug-abuser who died of progressive cytomegalovirus encephalitis despite successful treatment of cytomegalovirus retinitis with ganciclovir. On autopsy, complete remission of retinitis and widespread cytomegalovirus-encephalitis could be demonstrated. Therapeutic failure therefore seems attributable to insufficient CNS-distribution of ganciclovir rather than to ganciclovir-resistant cytomegalovirus strains.
Publication types
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Case Reports
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English Abstract
MeSH terms
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AIDS Dementia Complex / drug therapy*
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AIDS Dementia Complex / pathology
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Acquired Immunodeficiency Syndrome / drug therapy*
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Acquired Immunodeficiency Syndrome / pathology
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Adult
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Brain / pathology
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Cytomegalovirus Infections / drug therapy*
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Cytomegalovirus Infections / pathology
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Ganciclovir / therapeutic use*
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Humans
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Inclusion Bodies, Viral / ultrastructure
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Magnetic Resonance Imaging
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Male
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Opportunistic Infections / drug therapy*
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Opportunistic Infections / pathology
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Retinitis / drug therapy*
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Retinitis / pathology