Abstract
The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-lapachone showed an approximately the same trypanocidal activity of beta-lapachone. In addition, all the oxyranes showed less cytotoxicity than the corresponding naphthoquinones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / pharmacology*
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Cell Survival / drug effects
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Chlorocebus aethiops
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Dose-Response Relationship, Drug
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Fibroblasts / drug effects
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Fibroblasts / pathology
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Growth Inhibitors / pharmacology*
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Naphthoquinones / chemistry
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Naphthoquinones / pharmacology*
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Trypanosoma cruzi / drug effects*
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Trypanosoma cruzi / growth & development*
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Vero Cells
Substances
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Antiprotozoal Agents
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Growth Inhibitors
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Naphthoquinones
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beta-lapachone
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alpha-lapachone