Stabilizers and destabilizers controlling cell cycle oscillators

Daniele Guardavaccaro; Michele Pagano

doi:10.1016/j.molcel.2006.03.017

Stabilizers and destabilizers controlling cell cycle oscillators

Mol Cell. 2006 Apr 7;22(1):1-4. doi: 10.1016/j.molcel.2006.03.017.

Authors

Daniele Guardavaccaro¹, Michele Pagano

Affiliation

¹ Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.

PMID: 16600864
DOI: 10.1016/j.molcel.2006.03.017

Abstract

Various destabilizing factors of the ubiquitin system contribute to the synchrony and unidirectionality of the cell cycle clock by finely tuning the activity of various CDKs. The recent findings of hierarchical and connected waves of cyclin stabilizers highlight the complexity of this network.

Publication types

Review

MeSH terms

Animals
Cell Cycle / physiology*
Cyclin-Dependent Kinases / metabolism*
Eukaryotic Cells / physiology*
Humans
Models, Biological
Signal Transduction
Ubiquitin-Protein Ligase Complexes / physiology*
Ubiquitins / physiology*

Substances

Ubiquitins
Ubiquitin-Protein Ligase Complexes
Cyclin-Dependent Kinases