A polysaccharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro

Biotechnol Lett. 2006 Apr;28(8):539-43. doi: 10.1007/s10529-006-0011-x.

Abstract

A polysaccharide from the traditional Chinese medicinal herb, Bletilla striata (Thunb.) Reichb. f., was isolated, purified and characterized. It induced the proliferation of human umbilical vascular endothelial cells and the expression of vascular endothelial growth factor up to 156% and 147% of control after 72 h, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Dose-Response Relationship, Drug
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Galactose / analysis
  • Glucose / analysis
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mannose / analysis
  • Molecular Structure
  • Orchidaceae / chemistry*
  • Plants, Medicinal / chemistry
  • Polysaccharides / chemistry
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Spectroscopy, Fourier Transform Infrared
  • Time Factors
  • Vascular Endothelial Growth Factor A / biosynthesis*
  • Xylose / analysis

Substances

  • Polysaccharides
  • Vascular Endothelial Growth Factor A
  • Xylose
  • Glucose
  • Mannose
  • Galactose