Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1

Somat Cell Mol Genet. 1991 Sep;17(5):519-23. doi: 10.1007/BF01233176.

Abstract

Tumor necrosis factor, TNF, is a 17-kDa protein secreted by macrophages and classified as a cytokine. TNF binds to high-affinity receptors on the cell surface and is involved in a wide variety of biological responses. There are at least two types of receptors, tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2). The genes for TNFR1 a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 1 12 (12pter-cen) and (1pter-p32), respectively, by Southern blot analysis of human x Chinese hamster somatic cell hybrid panels. Recently, the corresponding genes in the mouse have been mapped to chromosomes 4 and 6 in regions that are conserved on human chromosomes 1 and 12.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 12*
  • Cricetinae
  • Cricetulus
  • Humans
  • Hybrid Cells
  • Receptors, Cell Surface / genetics*
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Receptors, Cell Surface
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha