Immunophenotypic characterization of peripheral blast cells in a leukemic miniature pig

Vet Pathol. 2006 May;43(3):362-7. doi: 10.1354/vp.43-3-362.

Abstract

The health status of a 4-year-old female, dd-haplotype miniature pig deteriorated rapidly, so the animal finally had to be euthanized because of poor clinical condition. Necropsy revealed a massive leukocytic infiltration in the parenchymatous organs of the abdominal cavity. On hematologic cell counting, severe leukocytosis (69.3 x 10(9) cells/liter) and high-grade basophilia (6.9 x 10(9) cells/liter) were evident. Cytologic examination, as well as analysis of expression of leukocyte differentiation antigens by means of flow cytometry, classified blasts, which accounted for about 22% of leukocytes, as biphenotypic cells co-expressing the myeloid marker SWC3 (CD172a) and the lymphoid markers CD5 and CD25. Hematologic features resembled those seen in humans with chronic myeloid leukemia at blast phase.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Female
  • Immunophenotyping
  • Leukemia / immunology
  • Leukemia / metabolism
  • Leukemia / pathology
  • Leukemia / veterinary*
  • Leukocytes / immunology
  • Leukocytes / metabolism*
  • Liver / pathology
  • Ovary / pathology
  • Swine
  • Swine Diseases / blood*
  • Swine Diseases / immunology*
  • Swine Diseases / metabolism

Substances

  • Biomarkers, Tumor