Abstract
We reported previously that a silicone tube whose inner surface has been implanted with negatively charged carbon ions (C-) enables a nerve to regenerate across a 15-mm inter-stump gap. In this study, we investigated whether a C- -ion-implanted tube pretreated with basic fibroblast growth factor promotes peripheral nerve regeneration. The C- -ion-implanted tube significantly accelerated nerve regeneration, and this effect was enhanced by basic fibroblast growth factor.
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Animals
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Carbon / therapeutic use
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Denervation
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Diffusion Chambers, Culture / standards
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Diffusion Chambers, Culture / trends
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Disease Models, Animal
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Fibroblast Growth Factor 2 / metabolism
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Fibroblast Growth Factor 2 / pharmacology*
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Fibroblast Growth Factor 2 / therapeutic use
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Growth Cones / drug effects
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Growth Cones / metabolism
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Growth Cones / ultrastructure
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Ions / therapeutic use
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Male
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Muscle, Skeletal / innervation
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Muscle, Skeletal / physiopathology
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Nerve Fibers, Myelinated / drug effects
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Nerve Fibers, Myelinated / metabolism
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Nerve Fibers, Myelinated / ultrastructure
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Nerve Regeneration / drug effects*
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Nerve Regeneration / physiology*
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Neural Conduction / drug effects
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Neural Conduction / physiology
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Prostheses and Implants / standards
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Prostheses and Implants / trends*
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Rats
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Rats, Sprague-Dawley
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Sciatic Nerve / drug effects*
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Sciatic Nerve / injuries
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Sciatic Nerve / metabolism
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Sciatic Neuropathy / drug therapy*
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Sciatic Neuropathy / metabolism
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Sciatic Neuropathy / physiopathology
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Silicones / therapeutic use
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Treatment Outcome
Substances
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Ions
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Silicones
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Fibroblast Growth Factor 2
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Carbon