Abstract
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Chromosomes, Human, Pair 17 / genetics
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Deception
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Dermatitis, Atopic / genetics*
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Female
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Gene Expression*
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Genetic Linkage*
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Haplotypes
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Humans
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Male
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Physical Chromosome Mapping
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Polymorphism, Single Nucleotide
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RNA, Messenger / metabolism
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Skin / chemistry
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Skin / metabolism
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Skin / pathology
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Suppressor of Cytokine Signaling 3 Protein
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Suppressor of Cytokine Signaling Proteins / analysis
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Suppressor of Cytokine Signaling Proteins / genetics*
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Suppressor of Cytokine Signaling Proteins / metabolism
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Up-Regulation
Substances
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RNA, Messenger
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SOCS3 protein, human
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Suppressor of Cytokine Signaling 3 Protein
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Suppressor of Cytokine Signaling Proteins