Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study

Cancer Lett. 2007 Mar 8;247(1):159-65. doi: 10.1016/j.canlet.2006.04.001. Epub 2006 May 11.

Abstract

Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (>20g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • DNA-Binding Proteins / genetics*
  • Endonucleases / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Lung Neoplasms / etiology
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Population Surveillance
  • RNA Polymerase I
  • Repressor Proteins
  • Risk Factors
  • Smoking / adverse effects*

Substances

  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • PPP1R13L protein, human
  • Repressor Proteins
  • POLR1G protein, human
  • RNA Polymerase I
  • ERCC1 protein, human
  • Endonucleases