Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report

Rev Inst Med Trop Sao Paulo. 2006 Mar-Apr;48(2):113-6. doi: 10.1590/s0036-46652006000200012. Epub 2006 May 8.

Abstract

We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Chronic Disease
  • Histoplasma / isolation & purification
  • Histoplasmosis / diagnosis*
  • Histoplasmosis / drug therapy
  • Humans
  • Itraconazole / therapeutic use
  • Male
  • Middle Aged
  • Mouth Diseases / diagnosis
  • Mouth Diseases / drug therapy
  • Mouth Diseases / microbiology*

Substances

  • Antifungal Agents
  • Itraconazole