An in vitro model has been developed to measure in-plane strains of the cement mantle, sandwiched between the tibial component and the underlying cancellous bone following total knee arthroplasty. Maximal in-plane strains occurred in the cement mantle below the contact points between the femoral and tibial components. These strains were significantly reduced by increasing the thickness of the polyethylene and even more impressively by metal backing. Eccentric loading, by as little as 5 degrees, increased the strains in the loaded compartment by 26 per cent and decreased those in the unloaded compartment by 62 per cent. The addition of torsion to axial loading did not significantly alter the principal direct strains or the principal shear strains. Although surface-covering tibial components have been advocated, continuous support of the cortical rim did not appear to be important in reducing cement mantle strains. While other studies have emphasized the critical stresses that may occur in the polyethylene tibial components of total knee implants, this study highlights the potential for localized cement fatigue with improperly sized components or with eccentric loading.