Facile purification of honokiol and its antiviral and cytotoxic properties

J Med Chem. 2006 Jun 1;49(11):3426-7. doi: 10.1021/jm060268m.

Abstract

A separation of honokiol 1 from the closely structurally related magnolol 2 was developed. Honokiol demonstrated weak activity against HIV-1 in human lymphocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Biphenyl Compounds / isolation & purification*
  • Biphenyl Compounds / pharmacology
  • Cell Line, Tumor
  • Chlorocebus aethiops
  • Drug Screening Assays, Antitumor
  • Humans
  • In Vitro Techniques
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / virology
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Vero Cells

Substances

  • Antineoplastic Agents, Phytogenic
  • Antiviral Agents
  • Biphenyl Compounds
  • Lignans
  • magnolol
  • honokiol