[Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr;28(2):240-3.
[Article in Chinese]

Abstract

Objective: To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese.

Method: Polymerase chain reaction sequence-based typing (PCRSBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese.

Results: A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%) , B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%).

Conclusion: The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics
  • Female
  • Gene Frequency*
  • Genetic Predisposition to Disease
  • HLA-B27 Antigen / classification
  • HLA-B27 Antigen / genetics*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Spondylitis, Ankylosing / genetics

Substances

  • HLA-B27 Antigen