A simple catalytic method for the regioselective halogenation of arenes

Org Lett. 2006 Jun 8;8(12):2523-6. doi: 10.1021/ol060747f.

Abstract

This paper describes a mild palladium-catalyzed method for the regioselective chlorination, bromination, and iodination of arene C-H bonds using N-halosuccinimides as oxidants. These transformations have been applied to a wide array of substrates and can provide products that are complementary to those obtained via conventional electrophilic aromatic substitution reactions. [reaction: see text]

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Hydrocarbons, Halogenated / chemical synthesis*
  • Molecular Structure
  • Palladium / chemistry*
  • Polycyclic Aromatic Hydrocarbons / chemistry*
  • Stereoisomerism

Substances

  • Hydrocarbons, Halogenated
  • Polycyclic Aromatic Hydrocarbons
  • Palladium