Comparison of prevalence rates of microbiological markers between bone/tissue donations and new blood donors in Scotland

Vox Sang. 2006 Jul;91(1):28-33. doi: 10.1111/j.1423-0410.2006.00777.x.

Abstract

Background and objectives: Blood-borne virus prevalence rates of samples accompanying tissue donors are not widely available. This article compares the rates in Scottish bone/tissue donors with those of new blood donors for the 7-year period, 1998-2004.

Materials and methods: Data were collated from existing internal reports. Age distributions of the donor populations were obtained by extracting information from existing computer databases.

Results: Scottish bone/tissue donors were found to have a fourfold higher prevalence for hepatitis B virus (HBV), a 1.6-fold higher prevalence for hepatitis C virus (HCV), an 11-fold higher prevalence for human T-cell lymphotropic virus (HTLV) and a 34-fold higher prevalence for syphilis compared with new blood donors. Excluding confirmed positives, the repeat-reactive rates for bone/tissue donors were similar to those of new blood donors.

Conclusions: The data demonstrated that the prevalence of blood-borne viruses in Scottish bone/tissue donors is higher than in new blood donors. We believe that the different age profiles of the two donor populations plays a significant role.

MeSH terms

  • Antibodies, Bacterial / blood*
  • Antibodies, Viral / blood*
  • Antigens, Viral / blood*
  • Biomarkers / analysis
  • Blood Donors*
  • Disease Transmission, Infectious / prevention & control
  • Female
  • Humans
  • Male
  • Prevalence
  • RNA, Viral / blood*
  • Retrospective Studies
  • Scotland
  • Syphilis / blood*
  • Syphilis / prevention & control
  • Tissue and Organ Procurement*
  • Transfusion Reaction
  • Virus Diseases / blood*
  • Virus Diseases / prevention & control

Substances

  • Antibodies, Bacterial
  • Antibodies, Viral
  • Antigens, Viral
  • Biomarkers
  • RNA, Viral