Abstract
We studied toxic effects of various schemes of cytostatic treatment on central and peripheral pools of hemopoietic precursor cells in patients with III-IV stages of lung cancer and breast cancer. It was found that erythro- and granulomonocytopoietic precursors are characterized by high resistance to cytostatic treatment compared to morphologically discernible bone marrow elements, which is probably a evolutionary developed property of this cell type aimed at rapid recovery of the hemopoietic tissue.
MeSH terms
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Antineoplastic Agents / pharmacology*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bone Marrow Cells / cytology
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Bone Marrow Cells / drug effects
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Breast Neoplasms / drug therapy*
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Erythrocytes / cytology
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Fluorouracil / therapeutic use
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Granulocytes / cytology
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Hematopoietic Stem Cells / cytology*
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Hemoglobins / metabolism
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Humans
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Lung Neoplasms / drug therapy*
Substances
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Antineoplastic Agents
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Hemoglobins
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Doxorubicin
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Cyclophosphamide
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Fluorouracil